Resource

Id:hg19/scores/CADD
Type:np_score
Summary: CADD score for functional prediction of a SNP. Please refer to Kircher et al. (2014) Nature Genetics 46(3):310-5 for details. The larger the score the more likely the SNP has damaging effect.
Description:

CADD

Downloaded from https://cadd.gs.washington.edu/download ;

Higher values of raw scores have relative meaning that a variant is more likely to be simulated (or "not observed") and therefore more likely to have deleterious effects.

Scaled scores are PHRED-like (-10*log10(rank/total)) scaled C-score ranking a variant relative to all possible substitutions of the human genome (8.6x10^9).

Please note the following copyright statement for CADD: "CADD scores (http://cadd.gs.washington.edu/) are Copyright 2013 University of Washington and Hudson-Alpha Institute for Biotechnology (all rights reserved) but are freely available for all academic, non-commercial applications. For commercial licensing information contact Jennifer McCullar (mccullaj@uw.edu).

Labels:
  • reference_genome: hg19/genomes/GATK_ResourceBundle_5777_b37_phiX174

Scores

id type default annotation description histogram range
cadd_raw float

cadd_raw

CADD raw score for functional prediction of a SNP. The larger the score the more likely the SNP has damaging effect HISTOGRAM FOR cadd_raw [-7.535, 35.789]
cadd_phred float

cadd_phred

CADD phred-like score. This is phred-like rank score based on whole genome CADD raw scores. The larger the score the more likely the SNP has damaging effect. HISTOGRAM FOR cadd_phred [0.000, 99.000]

Files

Filename Size md5
CADD.bedgraph.gz 79.37 GB 3a766a8e17649754371fdcafd4d1438d
CADD.bedgraph.gz.dvc 91.0 B 61b8c446d51719165655dd42b1ee5536
CADD.bedgraph.gz.tbi 2.6 MB 757558e9cc3731ea7ce629ff35ebb7b7
CADD.bedgraph.gz.tbi.dvc 91.0 B 89e4400ddd3349702b7654ff5ab5935c
genomic_resource.yaml 2.34 KB c85402fc7ea90535ccab2b5d077d5cee
statistics/