brain critical genes Uddin M, et al. Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder. Nat Genetics (2014) AAK1 ABCA2 ABCA3 ABCC5 ABCC8 ABCD2 ABCG2 ABCG4 ABI2 ACACA ACAP3 ACBD3 ACSL3 ACSL6 ACTL6B ADAM11 ADAM22 ADAM23 ADAMTS16 ADAMTS18 ADARB1 ADCY1 ADCY8 ADCYAP1R1 ADD1 ADD2 ADD3 AEBP2 AES AFF2 AFG3L1P AFTPH AGAP1 AGAP2 AGAP3 AGPAT4 AGTPBP1 AHI1 AJAP1 AKAP10 AKAP11 AKAP9 AKD1 AKT3 ALS2 AMER2 AMIGO1 AMPH AMZ2 ANAPC5 ANGEL2 ANK1 ANK2 ANK3 ANKRD12 ANKRD13B ANKRD13C ANKRD17 ANKRD26 ANKRD6 ANKS1B ANKS6 ANKZF1 ANLN ANO10 ANO4 ANP32E AP1G1 AP1S1 AP3B1 AP3B2 AP3M2 AP4B1 AP5M1 APBA1 APBA2 APBB1 APBB2 APC APLP1 APLP2 APOO APP APPL1 AQP4 AQR ARGLU1 ARHGAP19-SLIT1 ARHGAP22 ARHGAP26 ARHGAP29 ARHGAP33 ARHGAP44 ARHGDIG ARHGEF11 ARHGEF25 ARHGEF4 ARHGEF7 ARID4A ARID4B ARL1 ARL8A ARMC8 ARMC9 ARMCX5 ARMCX5-GPRASP2 ARNT2 ARPP21 ARVCF ASAP1 ASB3 ASIC1 ASIC2 ASPHD1 ASPHD2 ASTN1 ASTN2 ASXL1 ATCAY ATF2 ATG4C ATL1 ATP1B2 ATP2B1 ATP2B2 ATP2B3 ATP2C1 ATP6V1G2 ATP6V1G2-DDX39B ATP8A1 ATP8A2 ATRN ATRNL1 ATXN1 ATXN2 ATXN3 ATXN7L3B AUTS2 AVIL B3GAT1 B4GALNT1 B4GALNT4 B4GALT6 BAALC BAI1 BAI2 BAI3 BARHL2 BAZ2B BBS7 BCAN BCAS1 BCAS3 BCL11A BCL2L2 BCL2L2-PABPN1 BDP1 BEGAIN BEND6 BIN1 BIVM BIVM-ERCC5 BLCAP BMPER BMPR2 BPTF BRD8 BRD9 BRSK1 BRSK2 BRWD1 BRWD3 BSDC1 BSN BTBD1 BTBD10 BTBD9 BTN2A2 BTRC C10orf35 C11orf30 C12orf29 C12orf76 C14orf132 C14orf2 C14orf37 C15orf27 C17orf85 C18orf32 C1QTNF3 C1QTNF3-AMACR C1orf126 C1orf51 C1orf61 C20orf112 C20orf24 C20orf27 C2CD5 C3orf17 C4orf21 C5orf42 C5orf45 C8orf34 C8orf46 C9orf72 CA10 CA11 CA8 CABP1 CACHD1 CACNA1A CACNA1B CACNA1D CACNA1E CACNA1G CACNA2D1 CACNA2D2 CACNB3 CACNB4 CACNG2 CACNG7 CADM1 CADM3 CADM4 CADPS CADPS2 CALB2 CALN1 CAMK2B CAMK2G CAMK4 CAMKK1 CAMKK2 CAMKV CAMSAP1 CAMSAP2 CAMTA1 CAND1 CAPRIN2 CASD1 CASK CASKIN1 CATSPER2 CBLN1 CBX1 CCAR1 CCBL1 CCDC111 CCDC115 CCDC132 CCDC136 CCDC6 CCDC88A CCDC92 CCNC CCNG2 CCNJL CCNT2 CCNY CCP110 CCSAP CD200 CDC42BPA CDC42BPB CDC5L CDH10 CDH18 CDH20 CDH22 CDH23 CDH24 CDH7 CDHR3 CDIP1 CDK13 CDK14 CDK17 CDK5R1 CDK8 CDKL5 CDON CDR2L CDS1 CDYL2 CECR2 CELF3 CELF4 CELF5 CELF6 CELSR2 CELSR3 CENPT CEP120 CEP170 CEP192 CEP95 CERCAM CERKL CERS5 CERS6 CFL1 CHD2 CHD3 CHD6 CHD9 CHL1 CHM CHN1 CHRD CHRNB2 CHRNB3 CHST10 CIC CIT CKAP5 CLASP1 CLASP2 CLCN3 CLCN6 CLIP2 CLIP3 CLK4 CLSTN3 CLTC CLUHP3 CLVS1 CMC2 CNDP1 CNIH2 CNKSR2 CNOT2 CNOT6 CNTN1 CNTN2 CNTN4 CNTN6 CNTNAP1 CNTNAP2 CNTNAP4 CNTNAP5 COA5 COL13A1 COL19A1 COL27A1 CORO2B CPD CPLX1 CPLX2 CPLX3 CPNE6 CPNE9 CPT1C CRAMP1L CRB1 CRHR1 CRMP1 CRTAM CRTC1 CRY1 CSMD1 CSPG5 CSRNP3 CSTF3 CTIF CTNNB1 CTNND2 CTPS2 CTTNBP2 CUL9 CWC27 CWF19L2 CXXC1 CXorf23 CYP26B1 CYP46A1 DAAM1 DAB1 DAB2IP DACT1 DAGLA DBC1 DCAF17 DCAF8 DCC DCLK1 DCLK2 DCTN1 DCTN2 DCUN1D4 DDX26B DDX42 DDX6 DEAF1 DEF8 DENND4A DENND5B DEPDC5 DGCR8 DGKB DGKD DGKG DGKH DGKI DHX36 DICER1 DIRAS2 DISP2 DIXDC1 DLG1 DLG2 DLG3 DLG4 DLGAP1 DLGAP4 DLK2 DMTF1 DMXL1 DMXL2 DNAJB2 DNAJC17 DNAJC6 DNAJC7 DNER DNM1 DNMT1 DNMT3A DOCK3 DOCK4 DOCK9 DOK6 DOPEY1 DOPEY2 DPF1 DPF3 DPP10 DPP6 DPYSL2 DPYSL3 DPYSL5 DRG1 DROSHA DTNA DTNB DTX3 DUSP11 DVL2 DYNC1H1 DYNC1LI2 DYRK1A DZIP3 E4F1 EBAG9 ECE2 EDIL3 EFHA2 EFR3B EHBP1 EHMT1 EIF2B5 EIF4A2 EIF4E3 EIF4G2 EIF4G3 EIF6 ELAVL1 ELAVL3 ELAVL4 ELK4 ELMO1 ELMO2 ELMOD1 ELOVL4 ELP4 EMC4 EML5 ENAH ENO2 ENOX1 ENY2 EOMES EP400 EPB41 EPB41L1 EPB41L3 EPB41L4B EPB41L5 EPC2 EPHA6 EPHA7 EPHB1 EPHB2 ERC1 ERC2 ERCC3 ERCC6 ERGIC2 ERH ERP44 ESYT3 ETV1 EVL EXOC1 EXOC2 EXOSC10 EXT2 EZH1 FADS2 FAIM2 FAM120A FAM120C FAM126B FAM131B FAM135A FAM13B FAM160A2 FAM168A FAM171A2 FAM171B FAM179B FAM188A FAM193A FAM199X FAM19A5 FAM216A FAM217B FAM228B FAM5B FAM5C FAM73B FAM98B FAN1 FANCL FAT2 FAXC FBRSL1 FBXL14 FBXL16 FBXL20 FBXL3 FBXO11 FBXO16 FBXO27 FBXO3 FBXO9 FBXW11 FBXW7 FER FEZ1 FGF14 FGF17 FGF5 FGFR2 FIG4 FLT3 FMN2 FMNL2 FMR1 FN1 FNBP4 FOCAD FOXJ3 FOXK2 FOXN2 FOXP1 FRMD5 FRS2 FRY FSD1 FSTL4 FUBP3 FUT8 FUT9 FXYD7 FZD3 FZR1 G3BP2 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRG1 GABRG2 GAD1 GAD2 GALNT13 GALNT5 GALNT9 GAN GAP43 GARNL3 GDAP1L1 GDPD1 GEMIN7 GFAP GFOD1 GHITM GIGYF2 GIT2 GLCCI1 GLCE GLMN GLRA2 GLRB GLT25D2 GMFB GNAI1 GNAL GNAO1 GNAZ GNB3 GNB5 GNL1 GNPDA2 GNPTAB GOLM1 GPM6A GPM6B GPR107 GPR158 GPR158-AS1 GPR180 GPR37L1 GPR52 GPR75-ASB3 GPR83 GPR98 GPRASP1 GPRASP2 GRAMD1B GRIA1 GRIA2 GRIA3 GRIA4 GRID1 GRID2 GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRM1 GRM3 GRM4 GRM5 GSTA4 GTF2H4 GTPBP10 GUSBP4 HABP4 HACE1 HAPLN2 HAUS2 HAUS3 HCN1 HDAC2 HECTD2 HECTD4 HECW1 HERC1 HERC3 HERPUD2 HINFP HIPK1 HIPK2 HIST1H2BC HIST1H4E HIVEP2 HMG20A HMGCLL1 HMGCR HMP19 HNRNPA0 HNRNPH3 HNRNPR HOOK3 HP1BP3 HPCA HPCAL4 HR HRH3 HS3ST1 HSF4 ICA1L IDUA IFT46 IGFBP7 IGSF21 IGSF8 IKBKAP IL16 INPP4A INPP5F INTS3 INTS4 INTU IRX2 ITFG1 ITM2C ITPR1 ITSN1 IWS1 JAK2 JAKMIP2 JAM2 JARID2 JMJD1C JMJD7 JMJD7-PLA2G4B JMY JPH3 JPH4 KALRN KANSL2 KAT2A KAT6B KBTBD3 KCNA2 KCNAB1 KCNAB3 KCNC3 KCND2 KCND3 KCNH1 KCNH7 KCNIP1 KCNIP4 KCNJ6 KCNK1 KCNK10 KCNK12 KCNK9 KCNMB4 KCNN1 KCNN2 KCNQ2 KCNQ3 KCTD13 KCTD3 KCTD6 KCTD8 KDM2B KDM4C KHDRBS2 KHDRBS3 KIAA0319 KIAA0408 KIAA0430 KIAA0513 KIAA0895L KIAA0930 KIAA1033 KIAA1109 KIAA1191 KIAA1199 KIAA1324L KIAA1456 KIAA1468 KIAA1598 KIAA1704 KIAA1841 KIF1A KIF1B KIF21A KIF2A KIF3A KIF3C KIF5A KIF5B KIF5C KIFAP3 KIFC2 KIN KLC2 KLHL18 KLHL2 KLHL24 KLHL3 KLHL32 KLHL5 KLHL8 KNDC1 KPNA3 KREMEN2 KRIT1 KRT222 KSR2 L1CAM LANCL1 LAS1L LATS1 LCOR LDLRAD3 LEMD3 LENG8 LENG9 LEO1 LGALSL LGI1 LGI3 LHFPL4 LIMK1 LIN7C LIX1 LLGL1 LMAN1L LMBR1 LMBRD1 LMNB1 LMTK2 LOC100131825 LOC100379224 LONRF2 LPHN1 LPHN3 LPPR2 LRCH1 LRCH2 LRCH3 LRP1B LRRC40 LRRC7 LRRFIP2 LRRTM3 LRRTM4 LSAMP LSS LTN1 LUC7L LY6G5B LY6H LYPLAL1 LYST MACF1 MACROD2 MADD MAG MAGEE1 MAGI1 MAGI2 MAGI3 MAGOHB MAML3 MANEAL MAP1A MAP2 MAP2K5 MAP3K10 MAP3K12 MAP4 MAP4K2 MAP4K3 MAP4K4 MAP4K5 MAP6D1 MAP7D2 MAPK1 MAPK10 MAPK4 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MAPRE3 MAPT MARCH8 MARK1 MARK4 MAST1 MBD5 MBOAT2 MBTPS2 MCF2L MCF2L2 MCTP1 MCU MDGA1 MDN1 MEA1 MED12L MED13L MEGF10 MEGF11 MEGF8 METTL10 METTL21A METTL21D MGARP MGAT3 MGAT4A MGAT5B MID1 MINK1 MIR497HG MLL MLL2 MLL3 MLL5 MLST8 MMP16 MMP24 MMS19 MOG MON2 MORN1 MPDZ MPHOSPH6 MPHOSPH9 MPP6 MREG MRPL50 MRPS21 MRPS30 MSANTD3-TMEFF1 MSANTD4 MSH2 MTA3 MTERFD2 MTHFD1L MTMR9 MTPAP MTSS1L MTUS1 MUM1 MYCBP2 MYH10 MYO15A MYO5A MYT1 MYT1L N4BP2L2 NAA38 NAB1 NAE1 NALCN NAP1L2 NAP1L5 NAPB NAV2 NAV3 NBAS NBEA NCAM1 NCAM2 NCAN NCBP1 NCDN NCKAP1 NCOA1 NCOA2 NCOA6 NCOA7 NCOR1 NCS1 NDFIP1 NDP NDRG2 NDRG3 NDRG4 NDST3 NDUFA6 NEDD4L NEFH NEFL NEFM NEGR1 NEK1 NELL2 NEMF NEO1 NETO2 NEURL4 NEUROD2 NEUROD6 NF1 NF2 NFASC NFAT5 NINL NIPA1 NIPAL3 NKAIN1 NKAIN2 NKAIN3 NKIRAS1 NKTR NLGN1 NLGN2 NLGN3 NLGN4X NLK NMNAT2 NNAT NOL4 NOP58 NOVA1 NOVA2 NPAS3 NPAT NPFFR1 NPM2 NPPA-AS1 NPR2 NPTN NPTX1 NR1D1 NRBP1 NRCAM NRD1 NRIP2 NRSN1 NRSN2 NRXN2 NRXN3 NSD1 NSF NSG1 NTM NTRK2 NTRK3 NUAK1 NUDT3 NUFIP1 NUFIP2 NUP133 NUP153 NUP93 NXPH3 OCIAD1 OGFRL1 OLFM1 OLFM2 OLFM3 OPCML OPHN1 OSBP OSBP2 OSBPL2 OSBPL6 OSBPL7 OSBPL8 OTUB1 OTUD6B OTUD7A P2RX7 P4HTM PAAF1 PACS1 PACSIN1 PAGR1 PAK1 PAK3 PAK7 PALM PANK4 PAPD5 PAPL PAPSS1 PAQR6 PARD6A PARP2 PAX6 PAXIP1 PCBP3 PCCA PCDH9 PCDHGC3 PCF11 PCGF3 PCIF1 PCLO PCNXL2 PCYOX1L PDE1A PDE3B PDE4B PDIA2 PDP1 PDS5A PDS5B PDXP PDZD4 PEA15 PEG10 PEG3 PELI3 PER3 PEX1 PGAP1 PGBD5 PGM2L1 PHACTR3 PHF14 PHF21A PHKB PHTF1 PHYHIP PHYHIPL PI4KA PIGY PIGZ PIK3C3 PIK3R2 PIP4K2B PIP5K1C PITPNA PITPNC1 PITPNM1 PITPNM3 PKD1 PLA2G4B PLCB1 PLCB4 PLCG1 PLCL2 PLD5 PLEKHA6 PLEKHB1 PLEKHG5 PLK2 PLXDC2 PLXNA3 PLXNB3 PMP2 PMPCB PMVK POGZ POLA1 POLB POLE POLR3A POLR3F POU2F1 PPARGC1B PPFIA1 PPFIA2 PPFIA3 PPID PPIP5K1 PPME1 PPP1R11 PPP1R12A PPP1R16B PPP1R9B PPP2CA PPP2R2B PPP2R2C PPP2R2D PPP2R5B PPP3CA PPP3R1 PPP6R2 PRDM10 PRDM15 PRDM2 PRDX3 PREP PREX2 PRKACB PRKAG2 PRKAR2B PRKCE PRKCG PRMT7 PRMT8 PROSAPIP1 PROSER1 PRPF18 PRPF31 PRPF38B PRPF39 PRPF6 PRR3 PRRC2C PRRT1 PRRT2 PRTFDC1 PRUNE2 PSD PSD2 PSEN1 PSIP1 PSME3 PSPC1 PTCHD1 PTK2 PTK2B PTN PTPN13 PTPN5 PTPRA PTPRD PTPRG-AS1 PTPRN PTPRR PTPRS PTPRZ1 PUM2 PVALB PYURF QSER1 QSOX2 R3HDM1 R3HDM2 RAB11FIP4 RAB15 RAB1A RAB26 RAB37 RAB39B RAB3A RAB3C RAB3GAP2 RAB5A RAB6B RABGAP1L RALGAPA1 RALGAPB RALGDS RALGPS1 RALYL RAP1GAP2 RAP1GDS1 RAP2A RAPGEF2 RAPGEF4 RAPGEF6 RASGEF1A RASGEF1C RASGRF1 RASGRP1 RB1 RBFOX1 RBM15 RBM39 RCAN2 RCBTB1 RCOR3 RDH13 REC8 REEP2 REEP5 RELL2 RELN REPS1 REV1 REV3L RFC1 RFTN2 RFWD2 RFX3 RGS11 RGS12 RGS7 RGS8 RHBDL1 RHOT1 RICTOR RIF1 RIMS1 RIMS2 RIMS3 RIT2 RLF RNF112 RNF145 RNF146 RNF165 RNF182 RNFT2 RNGTT RPAIN RPAP3 RPH3A RPL17-C18orf32 RPRD1A RPRD2 RPS10-NUDT3 RPS6KA5 RPS6KL1 RSBN1 RTEL1 RTEL1-TNFRSF6B RTF1 RTN1 RUFY2 RUFY3 RUNDC3A RUNDC3B RUNX1T1 RUSC1 RYBP SALL2 SAMD14 SAR1A SART3 SATB2 SBF2 SCAI SCAPER SCG3 SCN1A SCN2A SCN2B SCN3A SCN3B SCN4B SCN8A SCRN3 SDC3 SDCCAG8 SEC24B SEC31A SEC31B SEC62 SECISBP2L SEL1L3 SEMA4F SEMA6A SENP6 SENP7 SEP15 SEPT3 SEPT4 SEPT8 SERF2 SERF2-C15ORF63 SERGEF SEZ6 SEZ6L SEZ6L2 SF3B1 SFPQ SGIP1 SGK196 SGTB SH3D21 SH3GL2 SH3GLB2 SHANK1 SHANK2 SHC3 SHF SHISA6 SHPRH SIPA1L1 SLAIN1 SLBP SLC12A2 SLC12A5 SLC17A7 SLC1A6 SLC22A15 SLC22A17 SLC23A2 SLC24A2 SLC24A3 SLC25A27 SLC25A40 SLC26A10 SLC26A5 SLC30A9 SLC32A1 SLC36A4 SLC4A10 SLC4A7 SLC4A8 SLC6A1 SLC6A15 SLC6A7 SLC7A14 SLC9A5 SLC9A6 SLCO1A2 SLIT1 SLITRK3 SLITRK5 SLK SLX4 SMAD4 SMARCA2 SMARCAD1 SMARCD3 SMC1A SMG1 SMG7 SNAP25 SNAPC3 SNCA SNCAIP SNCB SNTG1 SNX14 SNX2 SNX25 SNX27 SOGA1 SOGA2 SOGA3 SORBS2 SORL1 SORT1 SOS1 SOS2 SOX2 SPAG9 SPAST SPIN3 SPNS1 SPOCK2 SPOCK3 SPRYD3 SPTAN1 SPTBN2 SPTBN4 SRCIN1 SRGAP3 SRI SRRM4 SRSF11 SRSF7 SRSF9 SS18L1 SSTR2 ST18 ST6GAL2 ST8SIA1 ST8SIA3 ST8SIA5 STAM2 STAMBPL1 STARD4 STAU1 STK19 STK32C STK39 STMN1 STMN2 STMN3 STMN4 STRC STRIP1 STRN4 STX16 STX1A STX1B STX6 STXBP1 STXBP5 STXBP5-AS1 SULT4A1 SUPT3H SUPT7L SUV420H1 SUV420H2 SV2A SV2B SYBU SYN1 SYN2 SYN3 SYNDIG1 SYNE1 SYNGR1 SYNJ1 SYNPR SYP SYT1 SYT11 SYT12 SYT13 SYT14 SYT2 SYT3 SYT4 SYT5 SYT9 TAB2 TAF15 TAF1C TAF2 TAGLN3 TAOK3 TARBP1 TBC1D19 TBC1D5 TBC1D9B TBCEL TBCK TBRG1 TCEAL2 TCEB2 TCF12 TCF4 TCTN1 TDRKH TEF TELO2 TENM1 TFDP1 TGIF2-C20orf24 THAP10 THOC7 THRA THUMPD2 TIAM1 TIAM2 TLE2 TLK1 TLL1 TM2D3 TMC2 TMCC2 TMEFF1 TMEFF2 TMEM116 TMEM130 TMEM132A TMEM135 TMEM14C TMEM170A TMEM175 TMEM180 TMEM189-UBE2V1 TMEM196 TMEM200B TMEM241 TMEM25 TMEM30A TMEM50B TMEM59L TMEM74 TMEM9B TMTC2 TNIK TNK2 TNKS2 TNPO2 TNR TNRC6A TNRC6C TOP2B TOP3A TP53BP1 TPCN1 TPD52L2 TPGS2 TRA2A TRAK2 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC8 TRIM23 TRIM3 TRIM33 TRIM46 TRIM67 TRIM8 TRIM9 TRIO TRIP12 TRNAU1AP TRO TRPC1 TRPC3 TRPC4AP TRPM2 TRPM3 TRRAP TSC1 TSEN2 TSPAN5 TSPYL4 TTC21B TTC33 TTC37 TTC39B TTLL11 TTLL7 TUB TUBB2A TUBB2B TUBB3 TUBGCP6 TULP4 TUSC3 TYRO3 UBAP2L UBE2K UBE2O UBE2V1 UBP1 UBQLN1 UBTD2 UBTF UCK1 ULK2 UNC5C UNC79 UNC80 UPF3B URI1 USP16 USP20 USP21 USP31 USP32 USP33 USP34 USP45 USP46 USP48 USP9Y UTP18 UTP23 UXS1 VAMP2 VAPB VAT1L VOPP1 VPS13C VPS18 VPS29 VPS33B VPS37A VPS41 VPS53 VPS54 VSX1 VWC2 WASF1 WASF3 WASL WDFY3 WDR17 WDR19 WDR27 WDR41 WDR47 WDR67 WDR7 WDSUB1 WHSC1L1 WRAP73 WSCD1 WSCD2 WWC3 XKR6 XPO7 XRCC1 XYLT1 YEATS2 YLPM1 YME1L1 YPEL4 YTHDC2 YTHDF1 YTHDF2 YY1 ZBTB41 ZC2HC1A ZC3H15 ZCCHC12 ZDHHC17 ZDHHC21 ZDHHC4 ZDHHC8 ZEB1 ZFAND1 ZFC3H1 ZFHX2 ZFP1 ZFP112 ZFP30 ZFPM2 ZFYVE16 ZFYVE27 ZFYVE28 ZFYVE9 ZIC1 ZIC2 ZIC3 ZIC4 ZIM2 ZMYM2 ZMYM4 ZMYND11 ZMYND8 ZNF133 ZNF136 ZNF138 ZNF175 ZNF211 ZNF224 ZNF236 ZNF238 ZNF25 ZNF250 ZNF256 ZNF280D ZNF287 ZNF335 ZNF343 ZNF362 ZNF365 ZNF382 ZNF385D ZNF418 ZNF461 ZNF471 ZNF483 ZNF490 ZNF493 ZNF521 ZNF528 ZNF529 ZNF532 ZNF536 ZNF540 ZNF566 ZNF568 ZNF585A ZNF589 ZNF605 ZNF702P ZNF721 ZNF738 ZNF740 ZNF75A ZNF764 ZNF767 ZNF778 ZNF793 ZNF85 ZP2 ZSWIM8