Id:  gene_properties/gene_scores/LOEUF 
Type:  gene_score 
Version:  0 
Summary:  Degree of intolerance to predicted LossofFunction (pLoF) variation 
Description:  IntroductionDegree of intolerance to pLoF variation in each gene is assessed using the continuous metric of the observed/expected ratio. A confidence interval is estimated around the ratio. The lossoffunction observed/expected upper bound fraction (LOEUF) is the 90% upper bound of this confidence interval. Score definitionsLow scores or ranks indicate intolerance to loss of function mutations. Processing DetailsSupplementary Data, Table 11 downloaded on 2024 May 5 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334197/#MOESM1. DataPrep.py utilizes only scores for canonical transcripts (column canonical = TRUE). The 'oe_lof_upper' column in the downloaded file is used for LOEUF scores. LOEUF_ranks are calculated based on LOEUF scores. Resulting file LOEUF_scores.csv.gz has 3 columns: gene, LOEUF score, LOEUF rank. 
Labels: 
ID  Type  Description  Histograms  Range 

LOEUF 
90% upper bound for the confidence interval for observed/expected pLoF variation ratio
Small values desc: intolerant to pLoF variation
Large values desc: tolerant to pLoF variation


[0.030, 1.996]  
LOEUF_rank 
Gene ranks after sorting by LOEUF scores
Small values desc: intolerant to pLoF variation
Large values desc: tolerant to pLoF variation


[1.000, 19197.000] 
Filename  Size  md5 

DataPrep.py  1.09 KB  ec139d6ccbaa42ca8aa8c303b497155e 
LOEUF_scores.csv.gz  129.89 KB  2de3bb891f944af4d9cc3ac642294e99 
genomic_resource.yaml  1.79 KB  b3855f4060b82193109415a205a64f47 
supplementary_dataset_11_full_constraint_metrics.tsv.gz  13.02 MB  338a3ed667290813cafbb72eabcba2e0 
statistics/ 