Id: | gene_properties/gene_scores/LGD |
Type: | gene_score |
Version: | 0 |
Summary: |
Gene vulnerability/intolerance score based on the rare LGD variants |
Description: |
The LGD vulnerability score is described in https://pubmed.ncbi.nlm.nih.gov/26401017 and is based on relating the observed and expected numbers of ultra-rare LGD variants, where the expected number of ultra-rare LGDs in a gene is computed through a regression to the number of ultra-rare synonymous variants. The score is defined as the cumulative distribution function at the observed number of UR LGD variants of a Poisson distribution with a parameter equal to the expected number of UR LGD variants. |
Labels: |
ID | Type | Description | Histograms | Range |
---|---|---|---|---|
LGD_rank |
Gene rank after sorting by LGD vulnerability score
Small values desc: more likely to be vulnerable
Large values desc: less likely to be vulnerable
|
>
|
[1.000, 18394.500] | |
LGD_score |
Likelihood that a gene is vulnerable to damaging mutation
Small values desc: less likely to be vulnerable
Large values desc: more likely to be vulnerable
|
>
|
[0.000, 1.000] |
Filename | Size | md5 |
---|---|---|
LGD.csv | 497.77 KB | 4e9f0967f510d53285a51dfc33b4d06c |
genomic_resource.yaml | 1.41 KB | c11af27c8604c6e446ae3128a92f0d50 |
statistics/ |